NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. J Clin Invest 6: PLoS One 13 1:
Silencing suppressor of cytokine signaling-1 SOCS1 in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma IFN-gamma -dependent manner. Circ Res 1: PI3Kgamma activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. Mol Immunol 54 2: J Virol 91 Antagonistic function of the RNA-binding protein HuR and miRb in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Cell Biol 4: Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Arterioscler Thromb Vasc Biol 25 8: Sci Signal 10 J Clin Invest 7: A2B adenosine receptor expression by myeloid cells is proinflammatory in murine allergic-airway inflammation. Down-regulation of PLCgamma2-beta-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia. Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Cell Death Differ 20 PLoS One 8 Circ Res 4: J Immunol 9: Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. PLoS One 9 5:
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